Senior Research Associate BioAnalytics
Background

Citryll is a young and dynamic clinical stage therapeutic biotech company, located at the Pivot Park in Oss, The Netherlands. Citryll is taking a new approach to treat immune mediated inflammatory diseases including autoimmune diseases like Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), as well as skin and lung conditions. Citryll does this by specifically extinguishing the source of proinflammatory components, organ damaging components and autoantigens instead of broadly suppressing the acquired chronic inflammation.

Neutrophil extracellular traps (NETs), are part of the innate immune defense mechanisms but become pathogenic when their release is abundant and uncontrolled. Citryll’s lead anti-citrullinated histone antibody (ACHA) CIT-013 binds to N-terminal citrullinated epitopes on histones present in NETs, blocks NET formation, and promotes clearance of preformed NETs in tissues, all downstream of the protein citrullination pathway mediated by PAD enzymes. Inhibition of NET formation and accelerating clearance of preformed NETs reduces the exposure of autoantigens and toxic histones to the extracellular environment, leading to a decrease of proinflammatory mediators and protection of endothelial lining and organ tissue.

CIT-013 is a human antibody and is currently being tested in the clinic for safety & tolerability, PK and PD and the first clinical data have been evaluated. One proof of concept phase 2a clinical study is scheduled to start early 2023 and a second one later in 2023.
In Oss, the birthplace of many blockbuster drugs including the most successful PD1 antagonist antibody, we conduct various R&D elements of the CIT-013 program. This includes mechanism of action studies, research on new therapeutic use, bioanalytical assay development, clinical sample testing and pharmacological studies on patient neutrophils and whole blood.
Your role
You will work closely together with a small team of PhD scientists and (senior) research associates, and participate in:

  • Development and qualification of immunological and cell biological assays for (non)clinical sample analysis
  • Support the Bioanalytical team lead and assist in managing bioanalytical activities outsourced to CRO’s
  • Contribute to, and review scientific/bioanalytical protocols, reports, regulatory filings, SOPs and other guidelines;
  • Conduct scientific data review in accordance with current regulatory guidance and industry standards
  • Work closely together with CRO’s and contribute in managing outsourced regulated bioanalytical activities
  • [Keep track of critical timelines of bioanalytical activities together with the bioanalytical team lead]
  • Troubleshooting with respect to method development and initiation of improvements, where new ideas are valued
  • Supporting general laboratory activities
  • Presentation of experimental results and writing of development reports, and standard procedures (SOPs)
  • Full-time positions only (40 hours per week)
Competencies, qualifications & skills
  • BSc (HBO) or MSc (WO) or PhD degree in life sciences or related discipline.
  • ≥ 5 years of experience in a biotech or pharma company
  • Experience with assay development & qualification of cellular and immunological techniques like ELISA, Mesoscale Discovery and flow cytometry
  • Familiar with the regulatory guidelines for bioanalytical method development
  • Experience with transfer of bioanalytical methods to external service providers and familiarity with validation standards for bioanalytical assays
  • Proven excellent technical writing and oral communication skills in English
  • You are an accurate, flexible, quality-minded person that shows initiative and is able to work well in a team, as well as independently. You are goal oriented and result driven
  • You like to work in the environment of a dynamic biotech company where quality, speed, motivation, team spirit and results are of the utmost importance to be successful
  • You are or will be allowed to work in the EU.
  • Applicants without a permit to work in the EU or NL will not be considered
Interested?

Please send your CV and a short motivation letter via our contact form.  Also, you can use this form for informal enquiries about this vacancy before applying.

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