Senior Scientist Immunology
Background
Citryll is a young and dynamic company, located at the Pivot Park in Oss, The Netherlands. Citryll is taking a new approach to treat human diseases including autoimmune diseases like Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), and others by specifically extinguishing the source of autoimmunity and organ damage instead of broadly suppressing the acquired chronic inflammation.
Neutrophil extracellular traps (NETs), are part of the innate immune defense mechanisms but become pathogenic when their release is abundant and uncontrolled. Citryll’s lead tACPA (therapeutic anti-citrullinated protein antibody) CIT-013 program binds to N-terminal citrullinated epitopes on histones present in NETs and interferes with NET formation, function, and clearance downstream of the protein citrullination pathway. Inhibition of NET formation reduces the exposure of autoantigens and toxic histones to the extracellular environment, leading to a decrease of proinflammatory mediators and protection of endothelial lining and organ tissue.
Citryll has nominated a clinical development candidate CIT-013 that is being developed towards a proof of concept phase 1b clinical study which is scheduled to enter clinical development in 2021.
In Oss, the birthplace of many blockbuster drugs including the most successful PD1 antagonist antibody, we conduct various R&D elements of the CIT-013 programme. This includes mechanism of action studies, research on new therapeutic uses, bioanalytical assay development, clinical sample testing and pharmacological studies on patient neutrophils and whole blood.
Function
Are you a highly motivated scientific professional with expertise in cellular and molecular rodent and human immunology, eager to lead a small team in basic and translational research to progress CIT-013 for the treatment of autoimmune and inflammatory diseases, as well as other NETosis relevant target diseases disorders? 
As Senior Scientist Immunology you will be working in collaboration with Citryll team members in Oss and world-class external partners including CROs, academics and pharma and accelerate the progress of our therapeutic programs.
Description

You will work in a small team of scientists and technicians, and participate in:

  • Pharmacological studies in disease models human and rodent
  • Immunological analyse
  • Managing research associates, CROs and academic collaborations.
  • Write needed documentation, reports, patent applications and scientific papers
  • Full-time position (40 hours per week)
Competencies, qualifications & skills
  • At least 3 years of experience in a biotech or pharma company working experience in (translational) immunology and inflammatory diseases.
    Note:
    Recent graduates or academic postdocs cannot be considered
  • You are or will be allowed to work in the EU.
    Note:
    Please do not apply if you cannot work in the EU.
  • Ph.D. degree in immunology or a field relevant to immunology and inflammation with demonstrated expertise in these fields and its drug discovery, strongly supported by publications, patents, and training
  • Excellent technical writing and oral communication skills in English
  • Capable of working with tight deadlines
  • You are an accurate, flexible, quality-minded person that shows initiative and is able to work well in a team, as well as independently. You are goal oriented and result driven.
  • You like to work in the environment of a dynamic biotech company where quality, speed, motivation, team spirit and results are of the utmost importance to be successful.
  • Ability to manage and mentor scientists to foster a culture of innovation, teamwork, performance and trust.
Interested?

Please send your CV and a short motivation letter to info@citryll.com.

Please Note

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