Press release: Citryll Announces Dosing of the First Healthy Volunteer in a Phase 1 Clinical Trial for CIT-013, a First in Class Antagonist of NET Biology

OSS, The Netherlands – Citryll today announced that the first healthy volunteer has been enrolled and dosed in a Phase 1 clinical trial to evaluate the safety, tolerability, and pharmacokinetics of CIT-013. CIT-013 is a first in class humanized therapeutic antibody targeting Neutrophil Extracellular Trap (NET) formation and clearance. CIT-013 is being developed for autoimmune and chronic inflammatory diseases and other indications where NETs play an important role in pathogenesis.

  • First-in-human study evaluating CIT-013, a humanized monoclonal antibody targeting Neutrophil Extracellular Traps (NETs)
  • CIT-013 binds to citrullinated Histones H2A and H4
  • CIT-013 inhibits NET formation, promotes tissue NET clearance, and hence blocks the proinflammatory and toxic activities of NETs
  • Phase 1 SAD study expected to read-out by the end of 2021

The first-in-human study is a randomised, double blind, placebo controlled, single ascending dose (SAD) study carried out by the Centre for Human Drug Research (CHDR) in Leiden, The Netherlands, a CRO specialized in early-stage human clinical trials.

“We are very pleased with the progress made with our lead asset. This significant clinical milestone, recent preclinical studies in new indications, as well as partnering with the renowned CHDR for Citryll’s first in human studies all establish a platform for future success,” said Helmuth van Es, CEO of Citryll. “CIT-013 has the potential to impact many diseases where NET biology is contributing to pathology, such as lupus, rheumatoid arthritis, vasculitis, sepsis, a range of serious lung inflammatory conditions and the list is growing. The next phase of development is already in full preparation, including expanding to other countries for patient studies.”

“We are very pleased with the progress made with our lead asset. This significant clinical milestone, recent preclinical studies in new indications, as well as partnering with the renowned CHDR for Citryll’s first in human studies all establish a platform for future success”

“This is a very exciting step in the development of CIT-013” said Patrick Round, Citryll’s Chief Medical Officer. “Numerous non-clinical studies including disease models, human ex vivo and safety studies have demonstrated the potential of CIT-013 to inhibit NET formation, promote NET clearance and inhibit autoimmune and chronic inflammatory pathologies”.