Paul Peter Tak received his medical degree cum laude from the Free University in Amsterdam and was trained as an internist, rheumatologist and immunologist at Leiden University Medical Center, where he also received his PhD. He has worked as a scientist at the University of California San Diego. Next, he served as Professor of Medicine and founding Chair of the Department of Clinical Immunology and Rheumatology at the Academic Medical Centre/University of Amsterdam (AMC). His scientific work includes pioneering work on the cholinergic anti-inflammatory pathway (inflammatory reflex) in models of chronic inflammation and he led the first clinical trial in this field.
He has published extensively in peer-reviewed journals (570 publications, H-index 127, >70,000 citations), and served on numerous editorial boards, including as Co-Editor of Arthritis & Rheumatism. He received the Medal of Honour from the Netherlands Society for Rheumatology, was elected ‘Toparts Reumatologie’ (Elected by peers as ‘Best Rheumatologist’ in the Netherlands based on his clinical work making innovative therapies accessible to patients), was awarded Honorary Membership by EULAR and has been elected Fellow of the Academy of Medical Sciences in the U.K.
At GlaxoSmithKline he served as Senior Vice President, Chief Immunology Officer, and Global Development Leader. He oversaw the creation of a portfolio of potential medicines for immune-mediated inflammatory diseases, cancer, infectious disease and pain, including anti-OSM antibody, anti-LAG3 antibody, ESM-BET inhibitor, RIP1 kinase inhibitor, anti-GM-CSF antibody, anti-CCL17 antibody, molibresib, belantamab, and Benlysta sc. He was the Chair of the Scientific Review Board, the governing body accountable for the scientific assessment of GSK’s R&D portfolio.
He has served as President and CEO of Tempero Pharmaceuticals, President and CEO of Kintai Therapeutics, Board Member of Galvani Bioelectronics, ViiV Healthcare, Sitryx Therapeutics, Kintai Therapeutics, Omega Therapeutics, and Levicept.